Staff Scientist

Baylor College of Medicine
Houston, TX

Summary

We are seeking a highly motivated Staff Scientist to join our team investigating the mechanisms of T-cell dysfunction and immune evasion following allogeneic hematopoietic cell transplantation (allo-HCT). Our laboratory integrates expertise in epigenetics, chromatin regulation, and immunology to understand how altered gene regulatory programs drive T-cell exhaustion, impaired graft-versus-leukemia (GVL) responses, and post-transplant relapse in acute myeloid leukemia. The Staff Scientist will play a central role in developing and leading mechanistic projects, applying chromatin profiling, CRISPR functional genomics, and single-cell multi-omics to dissect the regulatory networks underlying T-cell dysfunction and identify therapeutic strategies to restore immune surveillance.

What We Offer

  • A highly collaborative environment bridging epigenetics, immunology, and cancer therapy.
  • Access to state-of-the-art single-cell platforms, CRISPR libraries, and mouse models for allo-HCT and leukemia.
  • Opportunities for professional growth, including mentorship in grant writing.

Job Duties

  • Lead mechanistic studies of donor T-cell dysfunction post-allo-HCT, with a focus on chromatin regulators, histone modifications, and transcriptional/epigenetic drivers of exhaustion.
  • Apply single-cell transcriptomics, epigenomics (ATAC-seq, CUT&Tag), and CITE-seq to map dysfunctional T-cell states in murine models and patient samples.
  • Use CRISPR/Cas9 screening and perturbation approaches to identify novel regulators of T-cell persistence, effector function, and exhaustion.
  • Collaborate with wet-lab and computational teams to integrate multi-omics datasets with clinical outcomes.
  • Mentor trainees and contribute to team science efforts, including multi-PI grants and translational collaborations.
  • Contribute to manuscripts, conference presentations, and grant applications.
  • Perform other job related duties as assigned.

Minimum Qualifications

  • Doctoral Degree. Experience may not be substituted in lieu of degree.
  • Three years of post doctoral research experience.

Preferred Qualifications

  • Ph.D. in Immunology, Epigenetics, Computational Biology, or related fields.
  • Strong publication record with first-author papers in relevant areas.
  • Demonstrated expertise in epigenetic/chromatin biology and its role in immune regulation or cancer biology.
  • Hands-on experience with T-cell biology, single-cell approaches, or CRISPR screening.
  • Strong data analysis skills and ability to work collaboratively across experimental and computational projects.
  • Experience studying T-cell exhaustion, GVHD/GVL biology, or allo-HCT models.
  • Knowledge of checkpoint pathways, metabolic regulation, or cytokine signaling in T cells.
  • Background in integrating clinical datasets with mechanistic studies.
  • Familiarity with drug discovery approaches (e.g., PROTACs, epigenetic inhibitors) that may reverse T-cell dysfunction.

 

 

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.

 

 

SN

Posted 2025-10-18

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